Recombinant Plasma Protein Therapeutics Market Report 2022 to 2030
The global recombinant plasma protein therapeutics market size is expected to reach US$ 21.7 bn by 2030 and anticipated expand at a CAGR of 9.2% from 2022 to 2030. Replacement of plasma derived proteins by recombinant plasma products, increase in the number of products launched, and rise in the demand for novel therapies of hemophilia treatment are anticipated to drive the market.
Rising Number of Regulatory Approvals to Drive Market
There has been an increase in the number of regulatory approvals in the last three years that have increased the availability of various options for patients with rare diseases such as hemophilia and other bleeding disorders. These approvals enabled companies to expand their product portfolios and gain competitive advantage. For instance, in September 2017, Ministry of Health, Labour and Welfare, Japan, approved CSL Behrings AFSTYLA, a recombinant factor VIII indicated for the treatment of hemophilia A. AFSTYLA has been also approved in the U.S., Canada, and Switzerland. In April 2018, Shire received Food and Drug Administration (FDA) approval for VONVENDI recombinant von Willebrand factor, indicated for perioperative management of bleeding in patients with von Willebrand disease (VWD). In July 2018, Bayer AG announced the approval for Kovaltry, recombinant factor VIII from the regulatory authorities in China, indicated for the treatment of hemophilia A.
Asia Pacific offering Numerous Growth Opportunities to the Market
In Asia Pacific, increase in the number of cases of rare hematology disorders, rise in adoption of recombinant DNA technology for therapeutic use, and surge in R&D expenditure by pharmaceutical & biotechnology companies are anticipated to drive the market. Additionally, the demand for third-generation recombinant coagulation factors is increasing in Japan and China, which further creates growth opportunities in the market. Government and non-government organizations are presently taking efforts to increase awareness about hemophilia A and hemophilia B, helping the general population to understand the cases, diagnosis, and treatment methods for such rare diseases. Countries such as China, Japan, Australia, and New Zealand are currently switching to recombinant plasma therapies as standard for hemophilia A treatment, with regulatory authorities. According to Hemophilia Foundation Australia, 80% of patients with bleeding disorders are treated with recombinant coagulation factors. Therefore, increase in the use of recombinant therapies for hemophilia treatment is expected to drive the market during the forecast period.
Strategic Approaches and Increasing Focus on R&D by Market Players
The report also provides profiles of leading players operating in the global recombinant plasma protein therapeutics market. These include CSL Limited, Shire (Takeda Pharmaceutical Company Limited), Octapharma, Novo Nordisk A/S, Bayer AG, Bioverativ Therapeutics, Inc. (Sanofi), Aptevo Therapeutics, Pharming Group NV, and Pfizer Inc.
New product launch, acquisition, geographical expansion, collaborations, and distribution agreements enable these companies to expand their presence in the global market. In January 2019, Shire was acquired by Takeda Pharmaceutical Company Limited, a pharmaceutical company based in Japan. With this acquisition, Takeda Pharmaceutical Company Limited is expected to strengthen its geographical presence. In January 2018, Sanofi, a leading pharmaceutical company, acquired Bioverativ Therapeutics Inc., which operated as a part of Sanofi Genzyme. Other market players have also undertaken numerous initiatives to expand their business in emerging markets. Leading market players are also focusing on increasing their customer base in countries in Asia Pacific such as China, Japan, and Australia. Market players are also supporting several campaigns for increasing awareness about hematological disorders and availability of treatment options such as recombinant plasma proteins and the advantages offered by these products.
The report analyzes and forecasts the recombinant plasma protein therapeutics market at global and regional levels. The market has been forecast based on volume (Tons) and value (US$ Mn) from 2020 to 2027. The study includes drivers and restraints of the global market. It covers the impact of these drivers and restraints on the demand during the forecast period. The report also highlights opportunities in the market at the global level. For the region and all segments, the sales, revenue and their market share, growth rate are key research objects; we can research the manufacturers' sales, price, revenue, cost and gross profit and their changes. What's more, we will display the main consumers, raw material manufacturers, distributors, etc.
This report first introduces the background of recombinant plasma protein therapeutics, including the definition, classification, application, industrial chain structure, industry overview, national policy and planning analysis of the industry, and the latest dynamic analysis. With regard to production bases and technologies, the research in this report covers the production time, base distribution, technical parameters, research and development trends, technology sources, and sources of raw materials of major recombinant plasma protein therapeutics companies.
Regarding the analysis of the industry chain, the research of this report covers the raw materials and equipment of recombinant plasma protein therapeutics upstream, downstream customers, marketing channels, industry development trends and investment strategy recommendations. The more specific analysis also includes the main application areas of recombinant plasma protein therapeutics and consumption, major regions and consumption, major global producers, distributors, raw material suppliers, equipment providers and their contact information, industry chain relationship analysis.
The report comprises a detailed value chain analysis, which provides a comprehensive view of the global recombinant plasma protein therapeutics market. The Porter’s Five Forces model has also been included to help understand the competitive landscape of the market. The study encompasses market attractiveness analysis, wherein various applications have been benchmarked based on their market size, growth rate, and general attractiveness.
The study provides a decisive view of the recombinant plasma protein therapeutics market by segmenting it in terms of form and application. The segment has been analyzed based on the present and future trends. Regional segmentation includes the current and projected demand in North America, Europe, Asia Pacific, Latin America, and Middle East & Africa.
The report provides size (in terms of volume and value) of recombinant plasma protein therapeutics market for the base year 2018 and the forecast between 2019 and 2026. Market numbers have been estimated based on form and application. Market size and forecast for each application segment have been provided for the global and regional market.
Companies Mentioned in Report
The report also profiles major players operating in the global recombinant plasma protein therapeutics market based on various attributes such as company overview, financial overview, product portfolio, business strategies, and recent developments. Key players profiled in the market report include CSL Limited, Shire (Takeda Pharmaceutical Company Limited), Octapharma, Novo Nordisk A/S, Bayer AG, Bioverativ Therapeutics, Inc. (Sanofi), Aptevo Therapeutics, Pharming Group NV, and Pfizer Inc.
The global recombinant plasma protein therapeutics market has been segmented as below:
Research Methodology:
In-depth interviews and discussions were conducted with several key market participants and opinion leaders to compile the research report.
Primary research represents a bulk of research efforts, supplemented by extensive secondary research. Annual reports, press releases, and relevant documents of key players operating in various application areas have been reviewed for competition analysis and market understanding.
Secondary research also includes recent trends, technical writing, Internet sources, and statistical data from government websites, trade associations, and agencies. These have proved to be reliable, effective, and successful approaches for obtaining precise market data, capturing market participants’ insights, and recognizing business opportunities.
The study objectives of this report are:
1. Preface
1.1. Market Definition and Scope
1.2. Market Segmentation
1.3. Key Research Objectives
1.4. Research Highlights
2. Assumptions and Research Methodology
3. Executive Summary : Global Recombinant Plasma Protein Therapeutics Market
4. Market Overview
4.1. Introduction
4.1.1. Product Definition
4.1.2. Industry Evolution / Developments
4.2. Overview
4.3. Market Dynamics
4.3.1. Drivers
4.3.1.1 Shift from use of Plasma Derived Proteins to Recombinant Therapies
4.3.1.2 Rising Awareness about Rare Disease Management
4.3.1.3 Increasing Focus on Investments in Rare Disease
4.3.2. Restraints
4.3.2.1 High Cost of Treatment
4.3.2.2 Availability of Alternative Therapies
4.3.3. Opportunities
4.3.3.1 Growth Opportunities in Developing Markets
4.3.3.2 Strategic Approaches such as Partnership and Distribution Agreements
4.4. Global Recombinant Plasma Protein Therapeutics Market Analysis and Forecast, 2019–2026
5. Key Insights
5.1. New Product Launch and Regulatory Approvals
5.2. Key Mergers & Acquisitions
5.3. Regulatory Scenario by Region/Country
6. Global Recombinant Plasma Protein Therapeutics Market Analysis and Forecast, by Drug Class
6.1. Introduction & Definition
6.2. Key Findings / Developments
6.3. Global Recombinant Plasma Protein Therapeutics Market Value Forecast, by Drug Class, 2019–2026
6.3.1. Recombinant Coagulation Factors
6.3.1.1. Recombinant Coagulation Factor VIII
6.3.1.2. Recombinant Coagulation Factor IX
6.3.1.3. Recombinant Coagulation Factor VIIa
6.3.1.4. Others
6.3.2. Human C1 Esterase Inhibitor
6.4. Global Recombinant Plasma Protein Therapeutics Market Attractiveness, by Drug Class
7. Global Recombinant Plasma Protein Therapeutics Market Analysis and Forecast, by Cell Line
7.1. Introduction & Definition
7.2. Key Findings / Developments
7.3. Global Recombinant Plasma Protein Therapeutics Market Value Forecast, by Cell Line, 2019–2026
7.3.1. Chinese Hamster Ovary (CHO) Cell Line
7.3.2. Baby Hamster Kidney (BHK) Cell Line
7.3.3. Human Embryonic Kidney (HEK) Cell Line
7.3.4. Others
7.4. Global Recombinant Plasma Protein Therapeutics Market Attractiveness, by Cell Line
8. Global Recombinant Plasma Protein Therapeutics Market Analysis and Forecast, by Indication
8.1. Introduction & Definition
8.2. Key Findings / Developments
8.3. Global Recombinant Plasma Protein Therapeutics Market Value Forecast, by Indication, 2019–2026
8.3.1. Hemophilia A
8.3.2. Hemophilia B
8.3.3. Von Willebrand Disease
8.3.4. Others
8.4. Global Recombinant Plasma Protein Therapeutics Market Attractiveness, by Indication
9. Global Recombinant Plasma Protein Therapeutics Market Analysis and Forecast, by Region
9.1. Key Findings
9.2. Global Recombinant Plasma Protein Therapeutics Market Value Forecast, by Region
9.2.1. North America
9.2.2. Europe
9.2.3. Asia Pacific
9.2.4. Latin America
9.2.5. Middle East & Africa
9.3. Global Recombinant Plasma Protein Therapeutics Market Attractiveness, by Region
10. North America Recombinant Plasma Protein Therapeutics Market Analysis and Forecast
10.1. Introduction
10.1.1. Key Findings
10.2. North America Recombinant Plasma Protein Therapeutics Market Value Forecast, by Drug Class, 2019–2026
10.2.1. Recombinant Coagulation Factors
10.2.1.1. Recombinant Coagulation Factor VIII
10.2.1.2. Recombinant Coagulation Factor IX
10.2.1.3. Recombinant Coagulation Factor VIIa
10.2.1.4. Others
10.2.2. Human C1 Esterase Inhibitor
10.3. North America Recombinant Plasma Protein Therapeutics Market Value Forecast, by Cell Line, 2019–2026
10.3.1. Chinese Hamster Ovary (CHO) Cell Line
10.3.2. Baby Hamster Kidney (BHK) Cell Line
10.3.3. Human Embryonic Kidney (HEK) Cell Line
10.3.4. Others
10.4. North America Recombinant Plasma Protein Therapeutics Market Value Forecast, by Indication, 2019–2026
10.4.1. Hemophilia A
10.4.2. Hemophilia B
10.4.3. Von Willebrand Disease
10.4.4. Others
10.5. North America Recombinant Plasma Protein Therapeutics Market Value Forecast, by Country, 2019–2026
10.5.1. U.S.
10.5.2. Canada
10.6. North America Recombinant Plasma Protein Therapeutics Market Attractiveness Analysis
10.6.1. By Drug Class
10.6.2. By Cell Line
10.6.3. By Indication
10.6.4. By Country
11. Europe Recombinant Plasma Protein Therapeutics Market Analysis and Forecast
11.1. Introduction
11.1.1. Key Findings
11.2. Europe Recombinant Plasma Protein Therapeutics Market Value Forecast, by Drug Class, 2019–2026
11.2.1. Recombinant Coagulation Factors
11.2.1.1. Recombinant Coagulation Factor VIII
11.2.1.2. Recombinant Coagulation Factor IX
11.2.1.3. Recombinant Coagulation Factor VIIa
11.2.1.4. Others
11.2.2. Human C1 Esterase Inhibitor
11.3. Europe Recombinant Plasma Protein Therapeutics Market Value Forecast, by Cell Line, 2019–2026
11.3.1. Chinese Hamster Ovary (CHO) Cell Line
11.3.2. Baby Hamster Kidney (BHK) Cell Line
11.3.3. Human Embryonic Kidney (HEK) Cell Line
11.3.4. Others
11.4. Europe Recombinant Plasma Protein Therapeutics Market Value Forecast, by Indication, 2019–2026
11.4.1. Hemophilia A
11.4.2. Hemophilia B
11.4.3. Von Willebrand Disease
11.4.4. Others
11.5. Europe Recombinant Plasma Protein Therapeutics Market Value Forecast, by Country/Sub-region, 2019–2026
11.5.1. Germany
11.5.2. U.K.
11.5.3. France
11.5.4. Spain
11.5.5. Italy
11.5.6. Rest of Europe
11.6. Europe Recombinant Plasma Protein Therapeutics Market Attractiveness Analysis
11.6.1. By Drug Class
11.6.2. By Cell Line
11.6.3. By Indication
11.6.4. By Country/Sub-region
12. Asia Pacific Recombinant Plasma Protein Therapeutics Market Analysis and Forecast
12.1. Introduction
12.1.1. Key Findings
12.2. Asia Pacific Recombinant Plasma Protein Therapeutics Market Value Forecast, by Drug Class, 2019–2026
12.2.1. Recombinant Coagulation Factors
12.2.1.1. Recombinant Coagulation Factor VIII
12.2.1.2. Recombinant Coagulation Factor IX
12.2.1.3. Recombinant Coagulation Factor VIIa
12.2.1.4. Others
12.2.2. Human C1 Esterase Inhibitor
12.3. Asia Pacific Recombinant Plasma Protein Therapeutics Market Value Forecast, by Cell Line, 2019–2026
12.3.1. Chinese Hamster Ovary (CHO) Cell Line
12.3.2. Baby Hamster Kidney (BHK) Cell Line
12.3.3. Human Embryonic Kidney (HEK) Cell Line
12.3.4. Others
12.4. Asia Pacific Recombinant Plasma Protein Therapeutics Market Value Forecast, by Indication, 2019–2026
12.4.1. Hemophilia A
12.4.2. Hemophilia B
12.4.3. Von Willebrand Disease
12.4.4. Others
12.5. Asia Pacific Recombinant Plasma Protein Therapeutics Market Value Forecast, by Country/Sub-region, 2019–2026
12.5.1. China
12.5.2. Japan
12.5.3. India
12.5.4. Australia & New Zealand
12.5.5. Rest of Asia Pacific
12.6. Asia Pacific Recombinant Plasma Protein Therapeutics Market Attractiveness Analysis
12.6.1. By Drug Class
12.6.2. By Cell Line
12.6.3. By Indication
12.6.4. By Country/Sub-region
13. Latin America Recombinant Plasma Protein Therapeutics Market Analysis and Forecast
13.1. Introduction
13.1.1. Key Findings
13.2. Latin America Recombinant Plasma Protein Therapeutics Market Value Forecast, by Drug Class, 2019–2026
13.2.1. Recombinant Coagulation Factors
13.2.1.1. Recombinant Coagulation Factor VIII
13.2.1.2. Recombinant Coagulation Factor IX
13.2.1.3. Recombinant Coagulation Factor VIIa
13.2.1.4. Others
13.2.2. Human C1 Esterase Inhibitor
13.3. Latin America Recombinant Plasma Protein Therapeutics Market Value Forecast, by Cell Line, 2019–2026
13.3.1. Chinese Hamster Ovary (CHO) Cell Line
13.3.2. Baby Hamster Kidney (BHK) Cell Line
13.3.3. Human Embryonic Kidney (HEK) Cell Line
13.3.4. Others
13.4. Latin America Recombinant Plasma Protein Therapeutics Market Value Forecast, by Indication, 2019–2026
13.4.1. Hemophilia A
13.4.2. Hemophilia B
13.4.3. Von Willebrand Disease
13.4.4. Others
13.5. Latin America Recombinant Plasma Protein Therapeutics Market Value Forecast, by Country/Sub-region, 2019–2026
13.5.1. Brazil
13.5.2. Mexico
13.5.3. Rest of Latin America
13.6. Latin America Recombinant Plasma Protein Therapeutics Market Attractiveness Analysis
13.6.1. By Drug Class
13.6.2. By Cell Line
13.6.3. By Indication
13.6.4. By Country/Sub-region
14. Middle East & Africa Recombinant Plasma Protein Therapeutics Market Analysis and Forecast
14.1. Introduction
14.1.1. Key Findings
14.2. Middle East & Africa Recombinant Plasma Protein Therapeutics Market Value Forecast, by Drug Class, 2019–2026
14.2.1. Recombinant Coagulation Factors
14.2.1.1. Recombinant Coagulation Factor VIII
14.2.1.2. Recombinant Coagulation Factor IX
14.2.1.3. Recombinant Coagulation Factor VIIa
14.2.1.4. Others
14.2.2. Human C1 Esterase Inhibitor
14.3. Middle East & Africa Recombinant Plasma Protein Therapeutics Market Value Forecast, by Cell Line, 2019–2026
14.3.1. Chinese Hamster Ovary (CHO) Cell Line
14.3.2. Baby Hamster Kidney (BHK) Cell Line
14.3.3. Human Embryonic Kidney (HEK) Cell Line
14.3.4. Others
14.4. Middle East & Africa Recombinant Plasma Protein Therapeutics Market Value Forecast, by Indication, 2019–2026
14.4.1. Hemophilia A
14.4.2. Hemophilia B
14.4.3. Von Willebrand Disease
14.4.4. Others
14.5. Middle East & Africa Recombinant Plasma Protein Therapeutics Market Value Forecast, by Country/Sub-region, 2019–2026
14.5.1. GCC Countries
14.5.2. South Africa
14.5.3. Rest of Middle East & Africa
14.6. Middle East & Africa Recombinant Plasma Protein Therapeutics Market Attractiveness Analysis
14.6.1. By Drug Class
14.6.2. By Cell Line
14.6.3. By Indication
14.6.4. By Country/Sub-region
15. Competitive Landscape
15.1. Market Player – Competition Matrix (By Tier and Size of companies)
15.2. Market Share Analysis By Company (2019)
15.3. Company Profiles
15.3.1. CSL Limited
15.3.1.1. Company Details
15.3.1.2. Products Portfolio
15.3.1.3. Financial Overview
15.3.1.4. Strategic Overview
15.3.1.5. SWOT Analysis
15.3.2. Shire (Takeda Pharmaceutical Company Limited)
15.3.2.1. Company Details
15.3.2.2. Products Portfolio
15.3.2.3. Financial Overview
15.3.2.4. Strategic Overview
15.3.2.5. SWOT Analysis
15.3.3. Octapharma
15.3.3.1. Company Details
15.3.3.2. Products Portfolio
15.3.3.3. Financial Overview
15.3.3.4. Strategic Overview
15.3.3.5. SWOT Analysis
15.3.4. Novo Nordisk A/S
15.3.4.1. Company Details
15.3.4.2. Products Portfolio
15.3.4.3. Financial Overview
15.3.4.4. Strategic Overview
15.3.4.5. SWOT Analysis
15.3.5. Bayer AG
15.3.5.1. Company Details
15.3.5.2. Products Portfolio
15.3.5.3. Financial Overview
15.3.5.4. Strategic Overview
15.3.5.5. SWOT Analysis
15.3.6. Pfizer Inc.
15.3.6.1. Company Details
15.3.6.2. Products Portfolio
15.3.6.3. Financial Overview
15.3.6.4. Strategic Overview
15.3.6.5. SWOT Analysis
15.3.7. Bioverativ Therapeutics, Inc. (Sanofi)
15.3.7.1. Company Details
15.3.7.2. Products Portfolio
15.3.7.3. Financial Overview
15.3.7.4. Strategic Overview
15.3.7.5. SWOT Analysis
15.3.8. Aptevo Therapeutics
15.3.8.1. Company Details
15.3.8.2. Products Portfolio
15.3.8.3. Financial Overview
15.3.8.4. Strategic Overview
15.3.8.5. SWOT Analysis
15.3.9. Pharming Group NV
15.3.9.1. Company Details
15.3.9.2. Products Portfolio
15.3.9.3. Financial Overview
15.3.9.4. Strategic Overview
15.3.9.5. SWOT Analysis
Cross-segment Market Size and Analysis for
Mentioned Segments
Additional Company Profiles (Upto 5 With No Cost)
Additional Countries (Apart From Mentioned Countries)
Country/Region-specific Report
Go To Market Strategy
Region Specific Market DynamicsRegion Level Market Share Import Export AnalysisProduction AnalysisOthers