Separation Systems for Commercial Biotechnology Market Size | Companies
The global separation systems for commercial biotechnology market size was estimated at around USD 25.63 billion in 2023 and it is projected to hit around USD 49.67 billion by 2033, growing at a CAGR of 6.84% from 2024 to 2033. Separation systems are critical components in commercial biotechnology, serving to purify and isolate biological materials like proteins, nucleic acids, and cells from complex mixtures. As biotechnology continues to advance, these systems are becoming increasingly important for pharmaceutical development, bioprocessing, and diagnostic applications. The global separation systems market is witnessing significant growth due to expanding biotechnological research, rising demand for biopharmaceuticals, and innovations in separation technologies.
The growth of the separation systems market for commercial biotechnology is driven by an increasing demand for biopharmaceuticals, such as vaccines, monoclonal antibodies, and cell-based therapies, which require precise and efficient separation processes during production. Additionally, advancements in bioprocessing technologies, including downstream processing, have led to the development of more innovative and efficient separation systems. The rise in biotechnology research, along with expanding applications in diagnostics, therapeutics, and drug development, is further propelling market growth. Lastly, the focus on sustainable biomanufacturing and regulatory requirements for product purity and safety are also contributing to the increasing adoption of advanced separation technologies in the biotech industry.
In 2023, North America led the separation systems market for commercial biotechnology, thanks to its well-established pharmaceutical and biotechnology sectors. Significant investments in R&D, combined with a robust regulatory framework, have driven the high demand for advanced separation technologies in the region. The focus on innovation and technological advancements, coupled with the presence of major biopharmaceutical companies and leading research institutions, further contributed to market growth.
| Attribute | North America |
| Market Value | USD 9.73 Billion |
| Growth Rate | 6.85% CAGR |
| Projected Value | USD 18.87 Billion |
The European market also saw significant growth in 2023, driven by strong investments in biopharmaceutical R&D and stringent regulatory standards for drug purity and quality. The region's emphasis on personalized medicine and biotechnological innovations has further boosted the adoption of advanced separation technologies. According to the Wallonia Export and Investment Agency, Belgium is at the forefront of biopharmaceutical R&D investment in Europe, spending nearly 70% more than Denmark and Slovenia. In 2021, Belgium approved 578 clinical trials, a 20% increase from the previous year, making it a leader in clinical trials per capita. The country also ranks second in biopharmaceutical patent applications per capita and third in the share of biopharmaceutical patents overall.
The Asia Pacific region is poised for substantial growth in the separation systems market, driven by expanding biopharmaceutical manufacturing capabilities in countries like China and India. Rising healthcare expenditures, along with significant investments in biotechnology infrastructure, are key factors fueling market growth. Additionally, the region's growing focus on developing innovative biotechnological solutions and the large patient population are accelerating the adoption of advanced separation technologies.
In 2023, conventional methods held a dominant market share of 70%, largely due to their proven reliability and cost-effectiveness. Techniques such as centrifugation and filtration have long been trusted for their efficacy and regulatory compliance, ensuring their continued use. Moreover, recent technological advancements have improved the efficiency and scalability of these traditional systems, making them a popular choice for large-scale biotech applications.
Modern methods are projected to experience the fastest growth, with a CAGR of 7.03% during the forecast period, as they offer greater precision and efficiency in separating complex biomolecules. Innovations in chromatography and membrane technologies have enhanced the purification process, driving demand for high-purity biopharmaceuticals. Additionally, increased investment in R&D for novel biotech applications is encouraging the adoption of advanced separation techniques. For example, in February 2024, Thermo Fisher Scientific Inc. introduced the Dionex Inuvion Ion Chromatography (IC) system, designed for flexible analyses of ions and small polar molecules, simplifying ion analysis for researchers at all levels.
The pharmaceutical segment led the market in 2023, accounting for 40% of the total market share. This dominance is attributed to the industry's growing focus on timely drug production, the rise of biopharmaceuticals, personalized medicine, and stringent purity standards. These factors are driving the demand for advanced separation techniques in pharmaceutical manufacturing.
The food and cosmetics segment is expected to grow at a CAGR of 7.03% over the forecast period, driven by increasing consumer awareness around natural and clean-label products. Improved extraction and purification technologies are resulting in safer, higher-quality products in both the food and cosmetics industries. Consumers' demand for organic, healthy products, along with stricter regulatory requirements, is prompting manufacturers to adopt advanced separation methods. For instance, in October 2023, Organic Harvest launched a toxin-free and cruelty-free makeup line, aligning with the growing demand for eco-friendly and safe beauty products that prioritize both skin health and environmental responsibility.
By Method
By Application
By Region
Chapter 1. Introduction
1.1. Research Objective
1.2. Scope of the Study
1.3. Definition
Chapter 2. Research Methodology
2.1. Research Approach
2.2. Data Sources
2.3. Assumptions & Limitations
Chapter 3. Executive Summary
3.1. Market Snapshot
Chapter 4. Market Variables and Scope
4.1. Introduction
4.2. Market Classification and Scope
4.3. Industry Value Chain Analysis
4.3.1. Raw Material Procurement Analysis
4.3.2. Sales and Distribution Channel Analysis
4.3.3. Downstream Buyer Analysis
Chapter 5. COVID 19 Impact on Separation Systems for Commercial Biotechnology Market
5.1. COVID-19 Landscape: Separation Systems for Commercial Biotechnology Industry Impact
5.2. COVID 19 - Impact Assessment for the Industry
5.3. COVID 19 Impact: Global Major Government Policy
5.4. Market Trends and Opportunities in the COVID-19 Landscape
Chapter 6. Market Dynamics Analysis and Trends
6.1. Market Dynamics
6.1.1. Market Drivers
6.1.2. Market Restraints
6.1.3. Market Opportunities
6.2. Porter’s Five Forces Analysis
6.2.1. Bargaining power of suppliers
6.2.2. Bargaining power of buyers
6.2.3. Threat of substitute
6.2.4. Threat of new entrants
6.2.5. Degree of competition
Chapter 7. Competitive Landscape
7.1.1. Company Market Share/Positioning Analysis
7.1.2. Key Strategies Adopted by Players
7.1.3. Vendor Landscape
7.1.3.1. List of Suppliers
7.1.3.2. List of Buyers
Chapter 8. Global Separation Systems for Commercial Biotechnology Market, By Method
8.1. Separation Systems for Commercial Biotechnology Market, by Method, 2024-2033
8.1.1. Conventional Methods
8.1.1.1. Market Revenue and Forecast (2021-2033)
8.1.2. Modern Methods
8.1.2.1. Market Revenue and Forecast (2021-2033)
Chapter 9. Global Separation Systems for Commercial Biotechnology Market, By Application
9.1. Separation Systems for Commercial Biotechnology Market, by Application, 2024-2033
9.1.1. Pharmaceutical
9.1.1.1. Market Revenue and Forecast (2021-2033)
9.1.2. Food & Cosmetics
9.1.2.1. Market Revenue and Forecast (2021-2033)
9.1.3. Agriculture
9.1.3.1. Market Revenue and Forecast (2021-2033)
9.1.4. Others
9.1.4.1. Market Revenue and Forecast (2021-2033)
Chapter 10. Global Separation Systems for Commercial Biotechnology Market, Regional Estimates and Trend Forecast
10.1. North America
10.1.1. Market Revenue and Forecast, by Method (2021-2033)
10.1.2. Market Revenue and Forecast, by Application (2021-2033)
10.1.3. U.S.
10.1.3.1. Market Revenue and Forecast, by Method (2021-2033)
10.1.3.2. Market Revenue and Forecast, by Application (2021-2033)
10.1.4. Rest of North America
10.1.4.1. Market Revenue and Forecast, by Method (2021-2033)
10.1.4.2. Market Revenue and Forecast, by Application (2021-2033)
10.2. Europe
10.2.1. Market Revenue and Forecast, by Method (2021-2033)
10.2.2. Market Revenue and Forecast, by Application (2021-2033)
10.2.3. UK
10.2.3.1. Market Revenue and Forecast, by Method (2021-2033)
10.2.3.2. Market Revenue and Forecast, by Application (2021-2033)
10.2.4. Germany
10.2.4.1. Market Revenue and Forecast, by Method (2021-2033)
10.2.4.2. Market Revenue and Forecast, by Application (2021-2033)
10.2.5. France
10.2.5.1. Market Revenue and Forecast, by Method (2021-2033)
10.2.5.2. Market Revenue and Forecast, by Application (2021-2033)
10.2.6. Rest of Europe
10.2.6.1. Market Revenue and Forecast, by Method (2021-2033)
10.2.6.2. Market Revenue and Forecast, by Application (2021-2033)
10.3. APAC
10.3.1. Market Revenue and Forecast, by Method (2021-2033)
10.3.2. Market Revenue and Forecast, by Application (2021-2033)
10.3.3. India
10.3.3.1. Market Revenue and Forecast, by Method (2021-2033)
10.3.3.2. Market Revenue and Forecast, by Application (2021-2033)
10.3.4. China
10.3.4.1. Market Revenue and Forecast, by Method (2021-2033)
10.3.4.2. Market Revenue and Forecast, by Application (2021-2033)
10.3.5. Japan
10.3.5.1. Market Revenue and Forecast, by Method (2021-2033)
10.3.5.2. Market Revenue and Forecast, by Application (2021-2033)
10.3.6. Rest of APAC
10.3.6.1. Market Revenue and Forecast, by Method (2021-2033)
10.3.6.2. Market Revenue and Forecast, by Application (2021-2033)
10.4. MEA
10.4.1. Market Revenue and Forecast, by Method (2021-2033)
10.4.2. Market Revenue and Forecast, by Application (2021-2033)
10.4.3. GCC
10.4.3.1. Market Revenue and Forecast, by Method (2021-2033)
10.4.3.2. Market Revenue and Forecast, by Application (2021-2033)
10.4.4. North Africa
10.4.4.1. Market Revenue and Forecast, by Method (2021-2033)
10.4.4.2. Market Revenue and Forecast, by Application (2021-2033)
10.4.5. South Africa
10.4.5.1. Market Revenue and Forecast, by Method (2021-2033)
10.4.5.2. Market Revenue and Forecast, by Application (2021-2033)
10.4.6. Rest of MEA
10.4.6.1. Market Revenue and Forecast, by Method (2021-2033)
10.4.6.2. Market Revenue and Forecast, by Application (2021-2033)
10.5. Latin America
10.5.1. Market Revenue and Forecast, by Method (2021-2033)
10.5.2. Market Revenue and Forecast, by Application (2021-2033)
10.5.3. Brazil
10.5.3.1. Market Revenue and Forecast, by Method (2021-2033)
10.5.3.2. Market Revenue and Forecast, by Application (2021-2033)
10.5.4. Rest of LATAM
10.5.4.1. Market Revenue and Forecast, by Method (2021-2033)
10.5.4.2. Market Revenue and Forecast, by Application (2021-2033)
Chapter 11. Company Profiles
11.1. Thermo Fisher Scientific Inc.
11.1.1. Company Overview
11.1.2. Product Offerings
11.1.3. Financial Performance
11.1.4. Recent Initiatives
11.2. QIAGEN
11.2.1. Company Overview
11.2.2. Product Offerings
11.2.3. Financial Performance
11.2.4. Recent Initiatives
11.3. Horizon Discovery Ltd.
11.3.1. Company Overview
11.3.2. Product Offerings
11.3.3. Financial Performance
11.3.4. Recent Initiatives
11.4. OriGene Technologies, Inc.
11.4.1. Company Overview
11.4.2. Product Offerings
11.4.3. Financial Performance
11.4.4. LTE Scientific
11.5. Oxford Biomedica PLC
11.5.1. Company Overview
11.5.2. Product Offerings
11.5.3. Financial Performance
11.5.4. Recent Initiatives
11.6. SignaGen Laboratories
11.6.1. Company Overview
11.6.2. Product Offerings
11.6.3. Financial Performance
11.6.4. Recent Initiatives
11.7. Flash Therapeutics
11.7.1. Company Overview
11.7.2. Product Offerings
11.7.3. Financial Performance
11.7.4. Recent Initiatives
11.8. Takara Bio Inc.
11.8.1. Company Overview
11.8.2. Product Offerings
11.8.3. Financial Performance
11.8.4. Recent Initiatives
11.9. Bio-Rad Laboratories, Inc.
11.9.1. Company Overview
11.9.2. Product Offerings
11.9.3. Financial Performance
11.9.4. Recent Initiatives
11.10. System Biosciences, LLC.
11.10.1. Company Overview
11.10.2. Product Offerings
11.10.3. Financial Performance
11.10.4. Recent Initiatives
Chapter 12. Research Methodology
12.1. Primary Research
12.2. Secondary Research
12.3. Assumptions
Chapter 13. Appendix
13.1. About Us
13.2. Glossary of Terms
Cross-segment Market Size and Analysis for
Mentioned Segments
Additional Company Profiles (Upto 5 With No Cost)
Additional Countries (Apart From Mentioned Countries)
Country/Region-specific Report
Go To Market Strategy
Region Specific Market DynamicsRegion Level Market Share Import Export AnalysisProduction AnalysisOthers