U.S. Bone Grafts and Substitutes Market (By Material Type: Allograft, Synthetic; By Application: Craniomaxillofacial, Dental, Foot & Ankle) - Industry Analysis, Size, Share, Growth, Trends, Revenue, Regional Outlook and Forecast 2024-2033

U.S. Bone Grafts and Substitutes Market Size and Trends

The U.S. bone grafts and substitutes market size was valued at USD 0.96 billion in 2023 and is anticipated to reach around USD 1.66 billion by 2033, growing at a CAGR of 5.63% from 2024 to 2033.

Key Pointers

• By Material Type, the allografts generated the maximum market share of 62% in 2023.
• By Material, the synthetic bone grafts segment is expected to expand at the highest CAGR of 7.43% from 2024 to 2033.
• By Application, the spinal fusion segment generated the maximum market share of 61% in 2023.
• By Application, the dental applications are estimated to expand the fastest CAGR of 8.73% from 2024 and 2033.

U.S. Bone Grafts and Substitutes Market Overview

The U.S. bone grafts and substitutes market is a dynamic sector within the healthcare industry, characterized by innovation, technological advancements, and a growing demand for effective solutions in orthopedic and dental procedures. This market encompasses a wide range of products designed to facilitate bone healing, regeneration, and reconstruction, catering to diverse patient needs and clinical requirements.

U.S. Bone Grafts and Substitutes Market Growth Factors

The growth of the U.S. bone grafts and substitutes market is propelled by an increasing incidence of musculoskeletal disorders and traumatic injuries drives the demand for effective bone healing solutions. Additionally, the expanding aging population contributes to a higher prevalence of degenerative bone diseases, further fueling market growth. Moreover, advancements in medical technology, including biomaterials and tissue engineering, enable the development of innovative bone grafting products with enhanced efficacy and biocompatibility. Furthermore, the rising adoption of minimally invasive surgical techniques and the expanding applications of bone grafts across various medical specialties amplify market opportunities.

U.S. Bone Grafts and Substitutes Market Trends:

• Rising Geriatric Population: The aging population in the U.S. is leading to an increased prevalence of degenerative bone diseases such as osteoporosis and osteoarthritis, driving the demand for bone grafts and substitutes to address bone defects and fractures associated with these conditions.
• Expanding Applications: Bone grafts and substitutes are finding expanding applications across various medical specialties beyond orthopedics and dentistry, including neurosurgery, spine surgery, and oncology, further driving market growth.
• Focus on Biologics: There is a growing emphasis on the development and use of biologic-based bone grafts and substitutes, such as demineralized bone matrix (DBM) and growth factors, due to their osteoinductive and osteogenic properties, as well as their potential to enhance bone healing.
• Patient-specific Solutions: Advancements in personalized medicine and patient-specific treatments are driving the development of customized bone grafting solutions tailored to individual patient needs, improving treatment outcomes and reducing the risk of complications.
• Cost-effectiveness and Reimbursement: With increasing pressure to contain healthcare costs, there is a growing focus on the cost-effectiveness of bone grafts and substitutes, with manufacturers exploring innovative pricing models and payers emphasizing value-based reimbursement strategies.
• Patient Education and Awareness: Efforts to educate patients and healthcare providers about the benefits and limitations of different bone grafting options are increasing, empowering patients to make informed decisions and fostering greater adoption of bone grafts and substitutes in clinical practice.

Material Type Insights

Allografts emerged as the dominant force in the market, commanding a substantial 62% share of revenue in 2023. This prominence can largely be attributed to the familiarity and inherent biocompatibility that allografts offer surgeons. Sourced from human tissues, allografts closely mirror the natural structure of bone, thereby facilitating osteoconductivity, where bone forms on the surface of the graft, potentially leading to quicker integration. Furthermore, the ample availability of allografts through tissue banks further solidifies their stronghold in the market.

On the other hand, the synthetic bone grafts segment is poised for the most rapid growth, with a projected compound annual growth rate (CAGR) of 7.43% from 2024 to 2033. This swift ascent is propelled by advancements in material science. Modern synthetic materials increasingly exhibit biocompatibility and osteoconductivity, mimicking the properties of natural bone. Additionally, synthetics offer distinct advantages over allografts, including a reduced risk of disease transmission and a virtually limitless supply regardless of donor availability. These factors are instrumental in propelling the robust growth trajectory of synthetic bone grafts within the U.S. market.

Application Insights

The spinal fusion segment emerged as the dominant force in the market, capturing a significant 61% share of revenue in 2023. This segment's prominence is fueled by the increasing prevalence of spinal conditions such as degenerative disc disease and spondylolisthesis. These conditions often necessitate spinal fusion surgeries to achieve stabilization and alleviate pain. With the aging population in the U.S. continuing to expand, the incidence rate of these spinal issues is anticipated to rise, further bolstering the demand for bone graft substitutes in spinal fusion procedures.

Conversely, dental applications are poised for substantial growth, with a projected compound annual growth rate (CAGR) of 8.73% between 2024 and 2033. This surge is attributed to the growing demand for dental implants and alveolar ridge augmentation procedures. Such procedures not only enhance the aesthetics but also improve the functionality of smiles, thereby driving the need for bone grafting materials in dentistry. The increasing emphasis on cosmetic dentistry and the rising disposable incomes among consumers are anticipated to propel the expansion of this segment even further.

U.S. Bone Grafts and Substitutes Market Key Companies

• Bioventus
• Medtronic
• NuVasive
• Osiris Therapeutics
• Stryker
• Zimmer Biomet
• BioHorizons
• Collagen Matrix
• Maxigen Biotech
• Osteogenics Biomedical

Recent Developments

• Smith+Nephew Acquires CartiHeal: In November 2023, Smith+Nephew successfully completed the acquisition of CartiHeal, the developer of the Agili-C implant, in a deal valued at up to USD 330 million. This strategic acquisition enhances Smith+Nephew's orthopedic portfolio and strengthens its position in the market.
• Orthofix Medical Inc. Receives FDA Clearance: In October 2023, Orthofix Medical Inc. received 510(k) clearance from the FDA for its innovative bioactive synthetic bone graft, OsteoCove. This new graft is designed to deliver superior bone formation capabilities, significantly expanding Orthofix's biologics portfolio and addressing a critical need within the market.
• Globus Medical and NuVasive Merger: In September 2023, Globus Medical finalized its acquisition of NuVasive, creating a leading musculoskeletal company. This merger brings together a comprehensive portfolio of solutions and enabling technologies, aimed at improving patient care across the entire continuum.

U.S. Bone Grafts and Substitutes Market Segmentation:

By Material Type

• Allograft
  • Demineralized Bone Matrix
  • Others
• Synthetic
  • Ceramics
• HAP
  • β-TCP
  • α-TCP
  • Bi-phasic Calcium Phosphates (BCP)
  • Others
  • Composites
  • Polymers
  • Bone Morphogenic Proteins (BMP)

By Application

• Craniomaxillofacial
• Dental
• Foot & Ankle
• Joint Reconstruction
• Long Bone
• Spinal Fusion